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Title   악성 흉막유출에서 섬유소용해계 물질의 변화 ( Fibrinolytic Profiles in Malignant Pleural Effusion )
Publicationinfo   1996 Jan; 028(04): 705-710.
Key_word   Malignant pleural effusion, Plasminogen activators and Plasminogen activator inhibitor-1
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Abstract   Plasminogen activators(PAs) and their inhibitors, plasminogen activator inhibitor-l(PAI-l) are known to play an important role in tumor invasion and metastasis. The differentiation of malignant pleural effusion(PE) from non-malignant pleural effusion is important for the management of a patient. Since malignant PE is a form of metastasis, and malignant cells are considered to be able to produce PAs or PAI-1, it seems reasonable to assume that PAa and PAI-1 in PE will be in somewhat different from that in non-malignant PE. We examined urokinase- type plasminogeo activator(uPA) and uPA receptor(uPAR) and tissue-type plasminogen activator(tPA), PAI-1 antigen using ELISA method and conventional laboratory tests and adenosine deaminase(ADA) in PEs. Levels of uPA, uPAR, tPA and PAI-1 were significantly increased in malignant and tuberculous PE than transudates(p<0.05) but not statistically significant between malignant and tuberculous PE. ADA in PE showed significantly increased in tuberculous PE than malignant PE and transudate(p<0.05). These data suggests that measurement of uPA, uPAR, tPA, PAI-1 antigen in addition to ADA could be helpful to differentiate malignant PE from tuberculous PE and transudate.
저 자   백승호(Seung Ho Baik),전진우(Jin Woo Jeon),원종호(Jong Ho Won),홍대식(Dae Sik Hong),박희숙(Hee Sook Park)